Maybe this will explain things.Brain fog is associated with many other diseases.Info is lower down on the page
International Scleroderma Network, SCLERO.ORG
Welcome to
SCLERO.ORG
* Visit Sclero Forums! *
Free online support in
English and Español
Mobile Devices:
Skip to Page Content
Home Medical News
Support Translations
Search sclero.org:
Help
How to Enable Javascript
for Site Menu
ISN Home
Home PageISN Organization Chart
and Volunteer Profiles
Organization ChartA-C
Abati, AngelaAcosta, MatildeAron, TorokBalbir-Gurman, Dr. AlexandraBarg, GaryBecker, DavidBlack, Professor CarolBridgman, IoneBulman, LisaCarina, IonaCastellanos, FranciscoCatoggio, Dr. LuisCzirjak, Dr. Laszlo
D-F
Davidoff, DinaDevlin, JudithDickson, StephenDistler, Dr. OliverDoom, SherylElsanousi, Dr. YasirEnsz, ShelleyEnsz, GeneFoster, Dr. C. Stephen
G-I
Hasegawa, MakiHopkins, LindaHowell, KevinIqbal, Dr. AsimIrvin, Dr. Liz
J-K
Jackson, JieJun, Dr. Jae-BumJustis, SerenaKalender, Dr. MehmetKurzen, FrancoiseKraft, Susie
L
Lamoli-Torres, EdwinLehman, Dr. ThomasLeon, AlbaLowe, BarbaraLowe, WayneLurtz, Krista
M
Maddoux, CarrieMagnani, GwenMahmud, Dr. TafazzulMakarov, YelenaMalcarne, Dr. VanessaManns, EarlMatucci-Cerinic, Dr. MarcoMcClelland, JeannieMiniati, Dr. IreneMolitor, Dr. JerryMoorthy, Dr. L. NandiniMueller-Ladner, Dr. UlfMyohanen, Emmi
N-Q
Novotny, JordanaPiche, SusannePope, Dr. Janet
R-S
Roar, PennyRoland, PamelaSato, Dr. SchinichiSeibold, Dr. James R.Seminara, LyndaSmith, Dr. RoySralla, PattySridharan, BanumathyStafilia, DimitraStrong, SandyStrong, Sid
T-Z
Thorpe, AmandaTrojanowska, MariaVarghese, TonyVolz, LisaWillis, Janey
How to Volunteer
Contact UsDonate or Shop
Donate Online (Main Page)Donate in MemoryMemorial DonorsScleroderma Awareness BraceletsScleroderma Can Koozies
ISN AwardsScleroderma Books
Voices of Scleroderma Volume 1Voices of Scleroderma Volume 2Voices of Scleroderma Volume 3
ISN Hope on the Horizon
Medical
Medical (Main)Autoimmune
Autoimmune (Main Page)A-C
AnemiaAntiphospholipidAnkylosing SpondylitisArthritisAsthmaAutoimmune Ear DiseaseAutoimmunityBehcet's?Cancer and SclerodermaCeliac and Gluten SensitivityChronic Fatigue Syndrome (CFS)
D-F
DepressionDermatologyDermatomyositisDiabetesEar DiseasesEhlers-DanlosEndometriosisEye DiseasesFatigueFibromyalgia
G-M
Graves' DiseaseGuillain-Barre SyndromeHashimoto's ThyroiditisIdiopathic Thromocytopenic PurpuraInterstitial CystitisLeukemiaLupus (SLE)Marfan SyndromeMixed Connective Tissue DiseaseMultiple Sclerosis (MS)Myasthenia Gravis (MG)
N-R
Neuromuscular DiseasesPancytopeniaPolyarteritis Nodosa (PAN)PolymyositisRheumatoid Arthritis (RA)
S-T
SarcoidosisSkin DiseasesSystemic Lupus Erythematosus (SLE)Thrombotic Thrombocytopenic Purpura (TTP) Thyroid DiseasesTuberculosis (TB)Tuberculous Fasciitis in Scleroderma
U-Z
Undifferentiated Connective
Tissue Disease (UCTD)VasculitisVulvodyniaWegener's Granulomatosis
Scleroderma
About SclerodermaCauses of SclerodermaDifficult DiagnosisPhotos of SymptomsResearch RegistriesScleroderma ExpertsScleroderma Symptoms
Symptoms (Main Page)BrainDental/MouthFatigueGastrointestinalHeart (Cardiac)Kidneys (Renal)Liver and SpleenLungs (Pulmonary)NeurologicalPregnancyRaynaud'sSjogren's (Dryness)Skeletal InvolvementSkin and Hair
Scleroderma Treatments
and Clinical Trials
Alternative TherapiesScleroderma Treatments and Clinical Trials (Main Page)
Types of Scleroderma
Types of SclerodermaJuvenileLocalized: Linear
and En Coup de SabreLocalized: MorpheaSystemic: CREST SyndromeSystemic: LimitedSystemic: DiffuseOverlap, MCTD, and UCTD
Skin Diseases
Newsroom
Newsroom (Main Page)Autoimmune NewsDonation and Website NewsMedia NewsNew Personal StoriesScleroderma Medical News
Support
Support (Main Page)Caregiver ResourcesEmotional Adjustment
Emotional Adjustment (Main Page)Anxiety and AttitudeCoping with SclerodermaDepressionPain ManagementQuality of LifeSexualitySleep DisordersSuicide Prevention
Disability Resources
Disability Resources (Main Page)Disability DiscussionsDisability InsuranceFree or Discounted MedsMedical Relief AgenciesMedical Alert ProgramsMobilityPatient RightsScholarships
Humor: Virtual Pity PartyPersonal Stories
Stories by First Name (A-Z)Stories by Type/SymptomsHow to Submit Your StoryStory Submission Form
Support Groups: U.S.Support Groups: WorldwideSclero Forums, Chats & Blogs!
Translations
Worldwide List (Main Page)Arabic ما هو تصلُّب الجلد؟Chinese 欢迎:硬皮病的概况Deutsche (German)EnglishEspañol (Spanish)Français (French)Greek (σκληρόδερμα;v)HebrewIndonesianItalianoJapaneseKannadaKoreanMagyarul (Hungarian)Malaysian: Apa dia Scleroderma?Nederlands: Over SclerodermiePolski (Polish)Português (Portuguese)Romana (Romanian)склеродермия? (Russian)TamilSkleroderma nedir? (Turkish)
* See YouTube Video Tour of Sclero.org! *
Popular Pages
•Scleroderma Experts
•ISN Medical Advisory
•Symptom Photos
Donate Vehicles, Cars, Trucks, Motorcycles, Snowmobiles, Boats to our nonprofit scleroderma charitable foundationPlease donate your used Car, Boat, Motorcycle or Snowmobile to the ISN to tackle scleroderma!
HonCode Accredited
This website is certified by Health On the Net Foundation. Click to verify.This site complies to the HONcode standard for trustworthy health information: verify here.
GuideStar Registration
We are a U.S. registered nonprofit 501(c)(3) charity, delivering stellar scleroderma research, support, education and awareness. Check our GuideStar listing!
How Can We Help You?
Please let us know how we can help you.
Warm Hugs,
Shelley Ensz,
ISN Founder & President
ISN Org Chart
Always Remember
The most important thing in the world to know about scleroderma is
www.sclero.org!
Donate
In Memory/Honor
Cars, Boats, Trucks...
Join
Newsletters
Sclero Forums (Free)
Shop
Awareness Bracelets
Scleroderma Books
SCLERO.ORG by the nonprofit International Scleroderma Network (ISN) is a full-service nonprofit charitable foundation providing stellar research, support, education and awareness
We are a nonprofit with 5,000+ pages in 22 languages!
Home Medical News *Sclero Forums* Support
Arabic Chinese Deutsche/German English Español Français Greek Hebrew Hungarian Indonesian Italiano Japanese Kannada Korean Magyarul Malaysian Nederlands Polski Português Romana Russian Spanish Tamil Turkish Worldwide
Brain (Cerebral) Involvement in Scleroderma
This page was written by Shelley Ensz, and has not yet been medically edited. Scleroderma (SD) affects everyone differently. Just because something is listed here does not mean that it is due to scleroderma or that an individual patient will ever experience it. See Disclaimer.
Overview of Brain Involvement
Steroids/Brain Atrophy Systemic Scleroderma
—Vascular Headache —What is Vertigo?
Localized Scleroderma Personal Stories
Related Links
Overview of Brain Involvement in Scleroderma
There are two main types of scleroderma: localized (such as morphea and linear) and systemic (such as CREST, limited, diffuse, and overlap.)
In a small study of 30 Russian patients presented at EULAR 2004, the systemic forms of scleroderma were associated with brain (cerebral) problems, such as chronic insufficiency of brain circulation. This research is preliminary and would need to be validated by larger studies before symptoms such as cognitive impairment, migraines and vertigo would be included in the diagnosis, evaluation, or classification of systemic scleroderma. See Systemic Scleroderma Brain Involvement.
Localized scleroderma, particularly linear scleroderma, has recently been associated with both focal and progressive brain lesions, progressive brain atrophy, epilepsy, neurological symptoms, intracerebral inflammatory processes, migraine headaches, and trigeminal neuralgia. Therefore, neuroimaging studies should be considered in all patients with linear scleroderma, and certainly when neurological symptoms occur. See Localized Scleroderma Brain Involvement.
Peripheral nervous system lesion syndromes and the mechanisms of their formation in connective tissue diseases. Systemic rheumatological diseases are often accompanied by the development of central and peripheral nervous system pathology. Lupus erythematosus and systemic scleroderma in particular are characterized by polyneuropathies and tunnel syndromes. PubMed. Neurosci Behav Physiol. 2007 Jan;37(1):1-6. (Also see: Lupus)
Cognitive Impairment in Systemic Sclerosis (SSc). Cognitive impairments are significantly more frequently encountered in SSc than in Rheumatoid Arthritis patients. The cause of such cognitive impairment remains to be investigated. Christine Moroni. 1873/545 ACR 2006.
Autoimmune brain inflammation studied. U.S. scientists say a key factor in development of brain inflammation may provide a new target for inflammatory diseases of the central nervous system. United Press International. 08/15/06.
Steroids and Brain Atrophy
Steroids and brain atrophy in multiple sclerosis. It appears that chronic low-dose treatment with corticosteroids may contribute to irreversible loss of brain tissue in a variety of autoimmune diseases. Evidence is mounting that high-dose corticosteroids may induce reversible short-term brain volume changes. Further longitudinal studies are needed to elucidate pathogenetic mechanisms contributing to brain volume fluctuations in autoimmune diseases and multiple sclerosis. PubMed. J Neurol Sci. 2005 May 5. (Also see: Multiple Sclerosis, and Medications)
Systemic Scleroderma Brain Involvement
In a small study of 30 Russian patients presented at EULAR 2004, the systemic forms of scleroderma were associated with brain (cerebral) problems, such as chronic insufficiency of brain circulation. This research is preliminary and would need to be validated by larger studies before symptoms such as cognitive impairment, migraines and vertigo would be included in the diagnosis, evaluation, or classification of systemic scleroderma.
Cerebral Vasculopathy Is Associated with Severe Vascular Manifestations in Systemic Sclerosis. Severe cerebral vasculopathy is associated with severe vascular manifestations in SSc patients. SSc patients with severe vascular complications should undergo neuroradiological imaging assessment of brain involvement. Benjamin Terrier. The Journal of Rheumatology. vol. 36 no. 7 1486-1494. July 2009. (Also see: Vascular Involvement)
Proton Magnetic Resonance Spectroscopy Reveals Central Neuroaxonal Impairment in Systemic Sclerosis. Involvement of the central nervous system (CNS) in systemic sclerosis (SSc) is rare. Evidence of neuroaxonal damage strongly suggests the existence of CNS involvement in SSc. J. Rheumatol 2006 March;33:546–51.
White matter hyperintensities on brain magnetic resonance in systemic sclerosis. White matter hyperintensities are more common in patients with SSc than in a CG (control group). These findings might be related to obliterative microvascular processes due to the disease. Early brain involvement in patients with SSc may occur. PubMed. Ann Rheum Dis. 2005 May;64(5):777-9.
Ischaemic stroke in progressive systemic sclerosis. We have documented a cerebral infarct in a PSS patient. In our opinion, the ischaemic stroke was caused by a localised autoimmune angiopathy. PubMed. Neurol Sci. 2004 Oct;25(4):230-233.
Hippocampal damage in mouse and human forms of systemic autoimmune disease. Taken together, these results suggest that systemic autoimmunity induces significant hippocampal damage, which may underlie affective and cognitive deficits in NP-SLE. PubMed. Hippocampus. 2004;14(5):649-61. (Also see: Lupus)
Cerebral vascular pathology in systemic sclerosis. The data obtained suggest that extra- and intracranial blood flow pathology in SS may, to a large extent, determine both organic brain lesion development in general and the genesis of many symptoms (headaches, vestibular disorders, etc). PubMed. Zh Nevrol Psikhiatr Im S S Korsakova. 2004;104(4):19-23.
Incidence of Cognitive Impairment in Systemic Sclerosis. Among the 17 patients, 13 had evidence for a cognitive impairment such as difficulties in performing two different cognitive tasks simultaneously, drawing elaboration, and memory impairment. Ten (59%) patients had a documented defect in long term memory research strategy, whereas 3 (17%) presented with short term defect. Only 3 of the 13 SSc patients who had cognitive impairment also had evidence for depression, as assessed by the MINI. C. Moroni. FRI0338 EULAR 2004.
Vestibular Balance Disorders: Vertigo, Motion Sickness, and Dizziness MedicineNet.
Magnetic Resonance Imaging (MRI) of the Brain in Patients with Systemic Sclerosis (SSC). Based on the findings of this study, albeit on a small number of patients, CNS involvement by SSc itself, does not seem to be substantiated. The need for studies in larger SSc populations is evident. A. P. Andonopoulos. AB0340 EULAR 2003.
What is a Vascular Headache?
Vascular Disease and Systemic Scleroderma. The vascular system is our circulatory system. It consists of all the vessels that carry blood and lymph through the body, to and from organs. Vessels include arteries, veins, and capillaries. Any condition that affects the vascular system, all of in part, is considered a vascular disease. ISN.
Overview of Vascular Disease
Vascular Involvement in Scleroderma
Types of Vascular Disease in Scleroderma
Vascular Disease in Other Connective Tissue Disease Biomarkers in Vascular Disease
Angiogenesis and Vascular Disease
Hypoxia and Vascular Disease Vascular Endothelial Growth Factor (VEGF)
Personal Stories
Related Information
Vascular Headaches Vascular headaches are usually throbbing in character, and physical exertion increases the pain. Included under the classification of vascular headaches are migraine headaches, cluster headaches, and toxic headaches. All involve dilation, or a swelling of the blood vessels. National Headache Foundation.
Migraine Is An Independent Risk Factor For Arterial Thrombotic Events (ATE) In Systemic Lupus Erythematosus (SLE). The presence and the frequency of migraine attacks, but not the duration of migraine was associated with ATE in SLE patients. S. Appenzeller. THU0228. EULAR 2008. (Also see: Lupus)
Headache, Hope Through Research Not all headaches require medical attention. Some result from missed meals or occasional muscle tension and are easily remedied. But some types of headache are signals of more serious disorders, and call for prompt medical care. National Institute of Neurological Disorders and Stroke.
What is Vertigo?
What is Vertigo? Vertigo is a symptom, not a disease. The term vertigo refers to the sensation of spinning or whirling that occurs as a result of a disturbance in balance (equilibrium). It also may be used to describe feelings of dizziness, lightheadedness, faintness, and unsteadiness. The sensation of movement is called subjective vertigo and the perception of movement in surrounding objects is called objective vertigo. Neurology Channel.
Overview of Localized Scleroderma Brain Involvement
Localized scleroderma has also recently been associated with brain involvement, particularly with linear scleroderma and the type known as scleroderma en coup de sabre or Parry Romberg's syndrome. Findings include focal and progressive brain lesions, progressive brain atrophy, epilepsy, neurological symptoms, intracerebral inflammatory processes, migraine headaches, and trigeminal neuralgia. Therefore, neuroimaging studies should be considered in all patients with linear scleroderma, and certainly when neurological symptoms occur.
Neuroimaging findings in scleroderma en coup de sabre. Localized scleroderma en coup de sabre is associated with focal, and in some progressive, brain lesions underlying the skin atrophy. Epilepsy, when present, is related to these brain lesions. Imaging findings and histopathology indicated that the process, most likely focal inflammatory, may be progressive. PubMed. Neurology. 2004 May 11;62(9):1585-9.
Neuroimaging Findings in Parry Romberg Syndrome and Scleroderma En Coup Sabre. In both syndromes there were signs of cortical abnormalities underneath the skin lesions. Whether this represents a cortical dysgenesis or a progressive degenerative/inflammatory lesion remains to be determined. Follow up brain imaging multicentric collaborative studies may clarify this issue. S. Appenzeller. AB0326 EULAR 2003.
Linear scleroderma "en coup de sabre" coexisting with plaque-morphea: neuroradiological manifestation and response to corticosteroids. Brain magnetic resonance imaging (MRI) showed focal T2 signal increases in the left frontoparietal region directly adjacent to the area of LSCS (Linear scleroderma "en coup de sabre"). Cerebrospinal fluid analysis revealed oligoclonal bands, suggesting an intracerebral inflammatory process. Subsequent pulsed corticosteroid treatment led to a remission of neurological symptoms and to a marked resolution of the MRI lesions. PubMed. J Neurol Neurosurg Psychiatry 2003 May;74(5):661-4.
Linear scleroderma associated with progressive brain atrophy. This study reports one case where neurological involvement may be associated with ipsilateral facial and skull involvement in disorders referred to clinically as LS 'en coup de sabre', and Parry Romberg syndrome. Neuroimaging studies should be considered in all patients with linear scleroderma, and such studies become necessary when neurological symptoms occur. Brain Dev 2003 Jan;25(1):57-61 PubMed.
Linear Scleroderma en Coup de Sabre and Brain Calcification: Is There a Pathogenic Relationship? We describe a female patient with linear scleroderma en coup de sabre and a longstanding clinical history of tonic and clonic convulsions. Radiographic study showed extensive cerebral calcifications in the right occipital hemisphere, homolateral to the involved side of her face. Brain imaging studies should be routinely performed in scleroderma patients exhibiting neurological manifestations, especially seizure disorder. DIANA ELSA FLORES-ALVARADO. J Rheumatol 2003;30:193-5.
Localized Scleroderma: Linear/En Coup de Sabre Linear Scleroderma can appear as a long streak resembling a deep sabre wound — often called "en coup de sabre." ISN.
Also see: Linear Scleroderma, En Coup de Sabre and Parry Romberg's Syndrome ISN.
Personal Stories: Cognitive, Headaches and Vestibular Disorders
There are many possible causes of cognitive problems, brain fog, headaches, migraines, dizziness, balance problems and vertigo. Just because these stories are listed here does not mean their particular symptoms are caused by scleroderma or by vascular complications of scleroderma or other illnesses.
Betty M: CREST Syndrome I was in so much pain for so long that I tried to take my own life. This only ended me up in a mental institution where I was given shock treatments that wiped out my whole memory...
Carla: CREST Syndrome and Fibromyalgia When I read some of these stories, they scare the devil out of me. Is this really that bad?...
Carol C: CREST Syndrome Scleroderma and Raynaud's have not robbed me of a fulfilling career...
Cedric: Linear Scleroderma, En Coup de Sabre (South Africa) I became aware of a small brown spot just above my right eye and gradually this patch became bigger and darker...
Cindy: Undifferentiated Connective Tissue Disease (UCTD) He seems to think that I have Systemic Lupus Erythematosus, but until my symptoms show more criteria for it, he can't call it that...
Debbie: CREST Here's a copy of a letter I sent to my rheumatologist....
Debby: CREST Scleroderma It was then everything added up— that I did not have several different conditions, but rather they were all part of the CREST...
Dienne: Morphea plus possible CREST I finally saw a rheumatologist about 6 years ago, who told me I had Raynaud's and Telangiectasia (spider veins)...
Faith Rumph: Eosinophilia-Myalgia Syndrome (EMS) I am one of several thousand Americans who became ill from ingesting contaminated over-the-counter L-tryptophan, an amino acid dietary supplement...
Gail: Undifferentiated Connective Tissue Disease (UCTD) They found I had Interstitial Cystitis, a positive ANA, and gastrointestinal dysmotility...
Gertie: Systemic Scleroderma without Skin Involvement or Raynaud's She looked thoughtful for a moment, then quietly asked "Is there hope?"
Gina: Morphea or Linear Scleroderma I really try to put it out of my mind and be thankful that it is not systemic...
Heidi: Difficult Diagnosis of UCTD Do these symptoms resemble the beginning symptoms for others who have gone on to be diagnosed with scleroderma?
Jewell: Diffuse Progressive Systemic Sclerosis When I think back, I had been getting sick for a long time. I just did not know it...
Joan Stovall: Scleroderma Dallas, Texas I may have scleroderma, but it does not have me...
Jody: Fibromyalgia/Difficult Diagnosis In Sudan, I was on IV for heat stroke and food poisoning. And in Thailand, at the end of March, it all came to a crashing halt...
Karen M.R.: Diffuse Scleroderma and Fibromyalgia I was so glad she was there, because I sort of went into shock when the doctor said she was going to start me on chemo treatments...
Kathi: Scleroderma/Lupus I am forty-three years old and have not been feeling well for ten years...
Kellie: Overlap Scleroderma and Mixed Connective Tissue Disease (MCTD) I am so relieved to read about so many people who have had the same experiences...
Linda F: CREST Scleroderma, Rheumatoid Arthritis, Fibromyalgia, Hashimoto's Thyroiditis, Hematoma, and Osteomyelitis I need to tell you all the gory details so you can truly understand what a miracle it is that I am alive today...
Lisa P: Undifferentiated Connective Tissue Disease (UCTD) I have an appointment with a new rheumatologist on May tenth. Hopefully I will get some answers...
Marie: CREST About 8 years ago, I noticed my fingers were going numb, turning white, while grocery shopping...
Mary S: Diffuse Scleroderma When he called the internist I was in the office and I heard him say, "I think I am sending you a patient who has scleroderma but I am not sure. She has a lot of the symptoms."
Monica: MCTD This diagnosis is a bittersweet one for us. Yes, after seven years of hell, we now have a name...
Robin: Difficult Diagnosis My rheumatologist said I have scleroderma, but just lately she said now she is not sure if it is that or fibromyalgia...
Patty S.:Localized Scleroderma, Pulmonary Hypertension and Sjögren's I have quit my job and reduced my stress a hundred percent. I am doting on my children and my husband...
Shar: Lupus, Scleroderma, Sjögren's, and Fibromyalgia Was my battle with Hepatitis C worth it? Yes!
Sherrill: Diffuse Systemic Scleroderma (New Zealand) I could no longer walk, due to knee contractures. My hands resembled claws. I had elbow contractures and neck contractures, and could not straighten my arms...
Sherry: Fibromyalgia, Hypothyroidism and Raynaud's He said Fibromyalgia is just pain, and if I could not handle my job, I should quit...
Sue W: UCTD with Neurological and Musculoskeletal Involvement Prior to this unique onset of symptoms I worked as a nurse and I was a very independent, self-sufficient single parent...
Tina Lech: Diffuse Scleroderma, Fibromyalgia, Pineal Cyst I was a very active, alive, mother of three...
William M: Scleroderma or Lupus I had to give up my career of being a registered nurse (RN) over two years ago due to total disability...
Related Links
An autopsied case of Sjogren's syndrome with massive necrotic and demyelinating lesions of the cerebellar white matter. PubMed. J Neurol Sci. 2004 Oct 15;225(1-2):143-8. (Also see: Sjogren's Syndrome)
Brain abscesses caused by Abiotrophia defectiva: complication of immunosuppressive therapy in a patient with connective-tissue disease. PubMed. Scand J Infect Dis. 2004;36(6-7):497-9. (Also see: Medications, Lupus, Sjogren's Syndrome, and Overlap Syndrome
Antiphospholipid Syndrome ISN.
Autoimmune Ear Disease ISN.
Cardiac Involvement ISN.
Chronic Fatigue Syndrome/Fibromyalgia ISN.
Gastrointestinal Involvement Gastrointestinal symptoms occur in a variety of neuromuscular diseases that may affect the neural access from the brain down to the peripheral nerve. ISN.
Scleroderma and Hypertension ISN.
Multiple Sclerosis ISN.
Neurological Involvement in Systemic Sclerosis ISN.
Scientists Build On Case Connecting Inflammatory Disease And Depression. Depressive disorders occur in 12 to 30 percent of patients who suffer from various diseases with an inflammatory component, including coronary heart disease and autoimmune diseases such as rheumatoid arthritis and inflammatory bowels. These mood disorders usually are attributed to psychological problems encountered by patients having to deal with the suffering and disability brought about by their diseases. However research on patients whose immune systems are boosted by immunotherapy challenge this view and suggest that depression may originate in the immune system. ScienceDaily 07/29/04. (Also see: Associated Conditions: Depression and Emotional Adjustment: Depression)
Raynaud's Raynaud's is an extreme spasm of blood vessels in response to cold or stress. The fingers and/or toes become white and/or blue, and may become red on re-warming. ISN.
Vasculitis is a general term for a group of diseases that involve inflammation in blood vessels. ISN.
Keep on Surfing!
Go to Cardiac (Heart) Involvement
Contact ISN. We are a full-service nonprofit scleroderma charitable foundation.
Email Inquiry Form (English)
Email Inquiry Form (Spanish)
Email Inquiry Form (Italian)
Email: isn@sclero.org
Or, post a message in our terrific
Sclero Forums Online Support Group!
International Scleroderma Network (ISN)
7455 France Ave So #266
Edina, MN 55435-4702
USA Toll Free Hotline in U.S.
1-800-564-7099
Direct Line
1-952-583-5735 (U.S.)
Arranging a Memorial, Fundraiser, Special Donation or P.R.?
(We are also known as the Scleroderma from A to Z web site.)
© Copyright 1998-2009 International Scleroderma Network
All Rights Reserved
Home Medical News Support Translations Donate